Реакция #5430

Уравнение реакции

potassium hydroxide

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

→

5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

Растворители

water

water ethanol

Условия реакции

Обработка

1. 1
   Температураthe mixture was refluxed for 2 hours
2. 2
   ДругоеThe solvent mixture was then removed under reduced pressure
3. 3
   ФильтрацияThe precipitated product was filtered off
4. 4
   Другоеdried

Методика

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

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