Реакция #54276

Уравнение реакции

1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride

acetone

hydrogen

→

1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride

Растворители

ethanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONTo the resulting solution are added 10 g
2. 2
   ДругоеAfter the absorption of hydrogen
3. 3
   Фильтрацияthe catalyst is filtered off
4. 4
   Концентрированиеthe filtrate is concentrated to dryness
5. 5
   ДругоеUpon recrystallization of the crude crystalline residue from isopropyl alcohol, 14.4 g

Методика

18.1 g. of 1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride are dissolved in 20 ml. of acetone and 300 ml. of ethanol. To the resulting solution are added 10 g. of extended Raney nickel and the mixture is heated and stirred at 70° C. in an atmosphere of hydrogen in an autoclave. After the absorption of hydrogen is complete, the catalyst is filtered off and the filtrate is concentrated to dryness. Upon recrystallization of the crude crystalline residue from isopropyl alcohol, 14.4 g. of 1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride are obtained as white needles.

Источник