Реакция #54243

Уравнение реакции

1-bromo-1-phenyl-3,3-dimethyl-butan-2-one

4-chlorophenol

sodium

→

1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one

Выход 67.0%

Растворители

ethyl acetate

ethanol

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   Другоеthe sodium bromide which had separated out
3. 3
   Фильтрацияwas filtered off hot
4. 4
   workup.DISTILLATIONThe filtrate was distilled in vacuo
5. 5
   Другоеthe solid residue which remained was recrystallized from ligroin

Методика

A solution of 25.4 g (0.1 mole) of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one in 50 ml of ethyl acetate was added dropwise, at the boil, to a solution of 12.85 g (0.1 mole) of 4-chlorophenol and 2.3 g (0.1 mole) of sodium in 100 ml of ethanol. After boiling for 12 hours under reflux, the sodium bromide which had separated out was filtered off hot. The filtrate was distilled in vacuo and the solid residue which remained was recrystallized from ligroin. 20.2 g (67% of theory) of 1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one of melting point 103° C. were obtained.

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