Реакция #5423

Уравнение реакции

N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea

dibromoethane

potassium carbonate

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

Выход 83.1%

Растворители

acetone

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed by distillation
2. 2
   Экстракцияthe residue was extracted with diethyl ether
3. 3
   ПромывкаThe extract was washed with water
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Концентрированиеconcentrated under reduced pressure
6. 6
   ДругоеThe residue was recrystallized from a mixture of hexane and ethanol

Методика

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

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