Реакция #541968

Уравнение реакции

2-(2-Chloroethoxy)ethanol

ethyl 4-hydroxybenzoate

potassium carbonate

→

ethyl 4-(2-(2-hydroxyethoxy)-ethoxy)benzoate

Выход 56.0%

Растворители

N,N-dimethylformamide

Условия реакции

Методика

2-(2-Chloroethoxy)ethanol (1, 0.18 mol), ethyl 4-hydroxybenzoate (2, 0.12 mol) and potassium carbonate (0.24 mol) were stirred in N,N-dimethylformamide (DMF) at 120° C. for 10 hours to obtain ethyl 4-(2-(2-hydroxyethoxy)-ethoxy)benzoate 3, followed by tosylation according to usual process to obtain a compound 4 in a yield of 56%.

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