Реакция #5418

Уравнение реакции

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

Выход 46.5%

Растворители

ethanol water

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 3 hours
2. 2
   ДругоеEthanol was removed by distillation under reduced pressure
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   ДругоеThe solvent was removed by distillation under reduced pressure

Методика

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

Источник