Реакция #54151

Уравнение реакции

2-hydroxy-4-methoxybenzaldehyde

ethyl acetoacetate

→

3-acetyl-7-methoxycoumarin

Условия реакции

Обработка

1. 1
   Температураwas warmed on a hot plate until solution
2. 2
   Температураto be heated gently
3. 3
   workup.WAITAfter several minutes the reaction mixture solidified
4. 4
   ТемператураAfter cooling
5. 5
   Другоеthe product was recrystallized from a mixture of alcohol and acetonitrile

Методика

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

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