Реакция #54140

Уравнение реакции

Nicotinoyl chloride hydrochloride

DIEA

meta-anisidine

CH2Cl2

→

Terpyridyl

Условия реакции

Обработка

1. 1
   ЭкстракцияThe solution was extracted with 1N HCl solution
2. 2
   Экстракцияextracted with CH2Cl2
3. 3
   Сушкаdried (MgSO4)
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated in vacuo
6. 6
   Другоеto give a white solid

Методика

Nicotinoyl chloride hydrochloride (0.3 g, 1.685 mmol), DIEA (0.65 g, 5.06 mmol, 3.0 eqv), and ortho- or meta-anisidine (0.21 g, 1.68 mmol, 1 eqv) were dissolved in CH2Cl2 and stirred at rt for 48 h. The solution was extracted with 1N HCl solution. The aqueous layer was neutralized with a NaHCO3 solution and extracted with CH2Cl2. The organic extracts were combined, dried (MgSO4), filtered, and concentrated in vacuo to give a white solid.

Источник