Реакция #541300

Уравнение реакции

2-(2-Chloroethoxy)ethanol

morpholine

potassium carbonate

→

2-(2-morpholinoethoxy)ethanol

Выход 34.2%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated
2. 2
   Температураat reflux for 6 hours
3. 3
   ДругоеThe insolubles were removed by filtration
4. 4
   Другоеthe volatiles were removed from the filtrate by evaporation
5. 5
   ДругоеThe residue was purified by column chromatography
6. 6
   Промывкаeluting with methylene chloride/methanol (95/5

Методика

2-(2-Chloroethoxy)ethanol (1.25 g, 10 mmol) was added to a mixture of morpholine (2.58 g, 30 mmol) and potassium carbonate (5.5 g, 40 mmol) in acetonitrile (50 ml). The mixture was heated at reflux for 6 hours and then stirred for 18 hours at ambient temperature. The insolubles were removed by filtration and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5 followed by 90/10 and then 80/20) to give 2-(2-morpholinoethoxy)ethanol (600 mg, 34%).

Источник