Реакция #54097

Уравнение реакции

6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline

2,3-dimethoxyphenyl boronic acid

K3PO4

→

6-(2,3-dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline

Выход 61.0%

Растворители

DMSO

Условия реакции

Обработка

1. 1
   ДругоеThe contents were placed in a microwave reaction vessel assembly
2. 2
   Другоеirradiated at 120° C. for 15 minutes
3. 3
   ДругоеPurification of the crude product by chromatography

Методика

6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (256 mg, 1.02 mmol) (Example 8) and 2,3-dimethoxyphenyl boronic acid (370 mg, 2.03 mmol) were combined in DMSO (2 mL). 2 M K3PO4 (1 mL) was added, followed by PdCl2(dppf) (50 mg). The contents were placed in a microwave reaction vessel assembly and irradiated at 120° C. for 15 minutes. The reaction was cooled to room temperature. Purification of the crude product by chromatography afforded 6-(2,3-dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline (190 mg, 61%) as a white solid.

Источник