Реакция #539252

Уравнение реакции

di-(imidazol-1-yl)methanone

5-aminobenzimidazole

2,6-difluoro-4-methoxybenzaldehyde

TMSCN

→

1-(1H-benzo[d]imidazol-5-yl)-5-(2,6-difluoro-4-methoxyphenyl)imidazolidin-2-one

Условия реакции

Обработка

1. 1
   ДругоеThe compound was synthesized
2. 2
   ДругоеThe product was purified by means of FPLC

Методика

The compound was synthesized starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 2,6-difluoro-4-methoxybenzaldehyde (0.688 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.2 mL, 8.6 mmol), di-(imidazol-1-yl)methanone (0.761 g, 4.69 mmol) as described in method 2. The product was purified by means of FPLC.

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