Реакция #53611

Уравнение реакции

Compound ( 29 )

((R)-1-Phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[cd]azulen-8-ylamine

hydrogen

→

titled compound ( 31 )

Выход 86.0%

(S)-2,7,8,9-Tetrahydro-6-oxa-2-azabenzo[cd]azulen-8-ylamine

Выход 86.0%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure
3. 3
   ДругоеThe residue obtained
4. 4
   Другоеwas chromatographed on aluminum oxide in chloroform

Методика

Compound (29) 609 mg was dissolved in tetrahydrofuran 20 ml. 20% Palladium(II)hydroxide 200 mg was added. A mixture was stirred in a hydrogen atomosphere for 22 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue obtained was chromatographed on aluminum oxide in chloroform to give the titled compound (31) as pale brown crystals, 337 mg. Yield 86%. Furthermore, this was recrystallized from methanol-isopropanol to give the titled compound (31) as pale brown crystals, m.p. 202-203° C.

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