Реакция #53429

Уравнение реакции

compound

1-Allyloxy-2-chloromethylbenzene

ammonia

→

(2-Allyloxy-benzyl)amine

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture is evaporated in vacuo
2. 2
   Другоеthe mixture is evaporated again
3. 3
   Экстракцияextracted several times with water
4. 4
   ДругоеThe aqueous phase is evaporated to a very great extent
5. 5
   Другоеan oil being obtained which
6. 6
   Другоеcrystallizes on standing

Методика

3.0 g (16.4 mmol) of the compound from Example I are boiled under reflux for 17 hours in 250 ml of a saturated methanolic ammonia solution. The reaction mixture is evaporated in vacuo, the residue is taken up in methanol and the mixture is evaporated again; this process is repeated a few times. The crude product is taken up in dichloromethane and extracted several times with water. The aqueous phase is evaporated to a very great extent, an oil being obtained which crystallizes on standing.

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