Реакция #5337

Уравнение реакции

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

Растворители

dioxane

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated to dryness
2. 2
   ДругоеThe residue was crystallized from ethyl acetate (50 ml)
3. 3
   ДругоеResulting crystalline precipitates
4. 4
   Фильтрацияwere collected by filtration

Методика

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

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