Реакция #53340

Уравнение реакции

compound XVIII

(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

chloroform

methyl isocyanate

→

(±)-1-{8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Выход 88.0%

Условия реакции

Обработка

1. 1
   ПромывкаAfter 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water
2. 2
   Концентрированиеafter concentration the obtained solid material
3. 3
   Другоеwas purified
4. 4
   Температураby refluxing in ethanol

Методика

To a stirred solution of 0.40 g (1.0 mmol) of compound XVIII in 15 ml of chloroform 0.07 ml (1.2 mmol) of methyl isocyanate was added. After 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water and after concentration the obtained solid material was purified by refluxing in ethanol. The desired product was 0.36 g, yield: 88%. Mp.: 200° C.

Источник