Реакция #5334

Уравнение реакции

4'-methylbiphenyl-2-carboxamide

N-bromo-succinimide

AIBN

→

4'-bromomethylbiphenyl-2-carboxamide

Растворители

benzene

Условия реакции

Обработка

1. 1
   ДругоеResulting crystalline precipitates
2. 2
   Фильтрацияwere collected by filtration
3. 3
   Промывкаwashed with isopropylether
4. 4
   workup.STIRRINGThe suspension was stirred for 30 minutes
5. 5
   Фильтрацияinsoluble materials were collected by filtration
6. 6
   Другоеdried
7. 7
   Другоеto give crude crystals
8. 8
   ДругоеRecrystallization from ethyl acetate methanol afforded colorless needles (1.6 g, 55%), m.p. 220°-221° C. (decomp.)

Методика

A mixture of 4'-methylbiphenyl-2-carboxamide (2.1 g), N-bromo-succinimide (2.5 g) and azobisisobutyronitrate (AIBN; 82 mg) in benzene (20 ml) was stirred for 20 hours at 60° to 70° C. Resulting crystalline precipitates were collected by filtration, washed with isopropylether and suspended in water. The suspension was stirred for 30 minutes, and insoluble materials were collected by filtration and dried to give crude crystals. Recrystallization from ethyl acetate methanol afforded colorless needles (1.6 g, 55%), m.p. 220°-221° C. (decomp.).

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