Реакция #533372

Уравнение реакции

sodium bicarbonate

2-cyano-6-(3-bromomethylbenzyloxy)benzothiazole

1-phenylpiperazine

→

product

Выход 48.2%

2-cyano-6-[3-(4-phenylpiperazin-1-yl)methylbenzyloxy]benzothiazole

Выход 48.2%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеAfter partition
2. 2
   Экстракцияthe aqueous phase was extracted with 20 mL of dichloromethane
3. 3
   Промывкаwashed with water twice
4. 4
   Сушкаdried over sodium sulfate
5. 5
   ДругоеThe solvent was removed
6. 6
   Другоеthe residue was purified by flash chromatography

Методика

To a solution of 2-cyano-6-(3-bromomethylbenzyloxy)benzothiazole (1 g, 2.8 mmol) in 20 mL of dichloromethane was added 1-phenylpiperazine (1.7 mL, 11.2 mmol) dropwise. The resultant solution was stirred at RT for 30 minutes. Then, 20 mL of saturated sodium bicarbonate solution was added. After partition, the aqueous phase was extracted with 20 mL of dichloromethane. The organic extracts were combined, washed with water twice and dried over sodium sulfate. The solvent was removed and the residue was purified by flash chromatography using 1% methanol in dichloromethane. 594 mg of product was obtained.

Источник