Реакция #53241

Уравнение реакции

guanidine carbonate

ethyl acetoacetate

→

6-methyl-iso cytosine

Выход 125.6%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ТемператураThe reaction solution was gradually heated
2. 2
   Температураto reflux temperature
3. 3
   ДругоеEthanol (300 mL) was evaporated
4. 4
   Температураthe reaction mixture was heated
5. 5
   Температураunder reflux for two hours
6. 6
   ТемператураAfter the reaction mixture was cooled
7. 7
   workup.ADDITION300 mL of hexane was added
8. 8
   ФильтрацияThe resulting precipitate was filtered
9. 9
   Промывкаwashed
10. 10
    Другоеdried

Методика

Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

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