Реакция #531807

Уравнение реакции

5-Benzyloxy-2-bromo-4-methoxy-phenol

5-Benzyloxy-2-bromo-4-methoxyphenol

NaH

CH3I

→

4

Выход 88.0%

1-Benzyloxy-4-bromo-2,5-dimethoxybenzene

Выход 88.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеflushed with Ar
2. 2
   workup.ADDITIONDry THF (50 mL) was added
3. 3
   workup.STIRRINGthe mixture stirred at room temperature under Ar for 18 h
4. 4
   ТемператураAfter cooling the reaction mixture in an ice bath
5. 5
   ЭкстракцияThe mixture was extracted with ethyl acetate
6. 6
   Другоеdried
7. 7
   Концентрированиеconcentrated
8. 8
   Другоеto give yellow oil that
9. 9
   ДругоеThe oil was purified by silica gel chromatography

Методика

5-Benzyloxy-2-bromo-4-methoxy-phenol 3 (2.76 g, 89.0 mmol) and NaH (0.89 g, 13.0 mmol, 60% dispersion in oil) were added to a flask and flushed with Ar. Dry THF (50 mL) was added and the suspension was stirred in an ice bath for 20 min. CH3I (1.7 mL, 27.0 mmol, filtered through basic alumina) was added and the mixture stirred at room temperature under Ar for 18 h. After cooling the reaction mixture in an ice bath, water was added slowly. The mixture was extracted with ethyl acetate, dried and concentrated to give yellow oil that solidified under vacuum. The oil was purified by silica gel chromatography using silica gel with (10% ethyl acetate/hexanes) to give 2.5 g (88%) of 4 as a white solid. 1H-NMR (400 MHz, CDCl3) dH 3.75 (3H, s, OCH3), 3.84 (3H, s, OCH3), 5.15 (2H, s, CH2Ph), 6.57 (1H, s, ArH), 7.07(1H,s,ArH), 7.32-7.42(5H,m,CH2Ph).

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