Реакция #531804

Уравнение реакции

Acetic acid

4-pentynoic acid

N-hydroxy succinimide

DCC

→

10a

Выход 100.5%

Pent-4-ynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Выход 100.5%

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.WAITthen left
2. 2
   workup.STIRRINGto stir at room temperature overnight
3. 3
   workup.WAIT(A white precipitate was observed after 15 min
4. 4
   ДругоеThe resulting DCU was removed by filtration
5. 5
   ДругоеThe filtrate was then evaporated

Методика

4-pentynoic acid (5.0 g, 51 mmol) and N-hydroxy succinimide (5.87 g, 51 mmol) were added to a solution of DCC (12.6 g, 61.2 mmol) in THF (125 ml) at −10° C. The mixture was then stirred for 1 h at −10° C. then left to stir at room temperature overnight. (A white precipitate was observed after 15 min). Acetic acid (0.63 ml) was then added. The resulting DCU was removed by filtration. The filtrate was then evaporated to give 10a (10 g, 100% crude yield).

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