Реакция #53169

ord-b27bcf3f1e8043e281f92c85bebdc2d9

Уравнение реакции

$CS(=O)(=O)N(CC(=O)O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

2-dimethylamino-ethylamine

HOBt

CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

TBTU

N-ethyl-N,N-diisopropylamine

→

$CN(C)CCNC(=O)CN(c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1)S(C)(=O)=O$

(Z)-3-{1-[4-(N-(2-dimethylamino-ethylaminocarbonylmethyl)-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

Реактанты

$CS(=O)(=O)N(CC(=O)O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

2-dimethylamino-ethylamine

HOBt

TBTU

N-ethyl-N,N-diisopropylamine

Реагенты

Нет

Растворители

DMF

Условия реакции

Подробные условия

See reaction.notes.procedure_details.

Методика

Prepared analogously to Example 18 from (Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone, 2-dimethylamino-ethylamine, HOBt, TBTU and N-ethyl-N,N-diisopropylamine in DMF.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06855710B2uspto-grants-2005_02