Реакция #5310

Уравнение реакции

Dihydropyran

4-chlorobutanol

→

title compound

Выход 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

Выход 89.9%

Условия реакции

Обработка

1. 1
   Промывкаwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   ТемператураThe dried liquid was heated under reduced pressure

Методика

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

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