Реакция #5309

Уравнение реакции

(3-Bromopropyl)benzene

magnesium

NH4Cl

oxetane

→

title compound

Выход 33.8%

Benzenehexanol

Выход 33.8%

Растворители

THF

Условия реакции

Обработка

1. 1
   Температураto maintain gentle reflux
2. 2
   Температураat reflux for 16 h
3. 3
   ЭкстракцияThe mixture was extracted with ER (3×75 ml)
4. 4
   Экстракцияthe dried extract
5. 5
   Другоеwas evaporated
6. 6
   Другоеto leave a yellow oil
7. 7
   workup.DISTILLATIONDistillation of the oil

Методика

(3-Bromopropyl)benzene (20 g) in THF (75 ml) was added dropwise to magnesium (2.43 g) at a rate to maintain gentle reflux. The mixture was stirred for 2 h at RT and oxetane (10 g) was added dropwise. The resulting suspension was stirred at RT for 2h and at reflux for 16 h and poured into saturated aqueous NH4Cl (100 ml). The mixture was extracted with ER (3×75 ml) and the dried extract was evaporated to leave a yellow oil. Distillation of the oil gave the title compound as a colourless liquid (6.05 g) b.p. 100-105°/0.4 mmHg. T.l.c. [O] 0.3.

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