Реакция #530742

Уравнение реакции

methylene chloride

2-chloro-6-hydrazinopyridine

2-(6-Chloro-2-pyridyl)trifluoroacetic acid, hydrazide

pyridine

methylene chloride

2-bromopropionyl chloride

→

2-(6-Chloro-2-pyridyl)-2-bromopropionic acid, hydrazide

Условия реакции

Обработка

1. 1
   workup.ADDITIONA mixture of 2.1 g
2. 2
   workup.ADDITIONis treated with 2.75 g
3. 3
   ДругоеAfter a heavy precipitate forms the ice bath is removed
4. 4
   ДругоеThe precipitate is collected
5. 5
   Промывкаwashed with methylene chloride
6. 6
   Другоеto provide 2.6 g

Методика

A mixture of 2.1 g. of 2-chloro-6-hydrazinopyridine (prepared in Example 1), 1.25 g. of pyridine and 50 ml. of methylene chloride is cooled to 10° C. and is treated with 2.75 g. of 2-bromopropionyl chloride in 5 ml. of methylene chloride according to the procedure of Example 2. After a heavy precipitate forms the ice bath is removed and the reaction mixture is stirred at room temperature for 1/2 hour. The precipitate is collected and washed with methylene chloride to provide 2.6 g. of the product of the Example as a colorless solid m.p. 184° C.

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