Реакция #52986

Уравнение реакции

3,5-dimethoxybenzyl alcohol

tert-butyl-diphenylsilyl chloride

imidazole

→

3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether

Выход 87.9%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеDMF was evaporated
2. 2
   Другоеthe residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% )

Методика

A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% ) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).

Источник