Реакция #52983

Уравнение реакции

3,5-dimethoxybenzyl alcohol

t-butyl-diphenylsilyl chloride

imidazole

→

3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene

Выход 87.9%

Условия реакции

Обработка

1. 1
   ДругоеDMF was evaporated
2. 2
   Другоеthe residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%)

Методика

A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), t-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DML (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%) to yield 8.5 g of 3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene. ESMS: m/z 407 (MH+).

Источник