Реакция #52642

Уравнение реакции

4-anisidine

hydrochloric acid

hydroxylamine hydrochloride

chloral hydrate

sodium sulfate

→

N—(2-hydroximinoacetyl)anisidine

Выход 85.2%

Растворители

water

water

water

Условия реакции

Обработка

1. 1
   Другоеwas held at 60° C.
2. 2
   workup.ADDITIONThe first solution was then added to the second and the reaction
3. 3
   Температураwas refluxed for 2 minutes
4. 4
   Температураcooled in an ice bath
5. 5
   ДругоеThe tan precipitate which formed
6. 6
   Фильтрацияwas collected by vacuum filtration
7. 7
   Промывкаwashed with water
8. 8
   Другоеdried under vacuum

Методика

A solution of 11.4 g of hydroxylamine hydrochloride in water (50 ml) was added to a solution of chloral hydrate (9.6 g) and sodium sulfate (83 g) in water (200 ml) at 60° C. The mixture was held at 60° C. while, in a separate flask, a solution of 4-anisidine (6.4 g) and concentrated hydrochloric acid (4.3 ml) in water (80 ml) was warmed to 80° C. The first solution was then added to the second and the reaction was refluxed for 2 minutes, cooled slowly to room temperature and then cooled in an ice bath. The tan precipitate which formed was collected by vacuum filtration, washed with water and dried under vacuum to give 8.6 g (85% yield) of N—(2-hydroximinoacetyl)anisidine.

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