Реакция #52544

Уравнение реакции

4-ethynyl-2-isopropyl-1-(1-methyl-cyclopropoxymethyl)-benzene

Intermediate 166

4-ethynyl-2-isopropyl-1-(1-methyl-cyclopropoxymethyl)-benzene

methyl-(4-iodophenyl)-acetate

4-iodo phenyl acetic acid methyl ester

Reagent B

4-iodo phenyl acetic acid methyl ester

→

title compound

Выход 60.2%

Methyl{4-[3-isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-phenyl}-acetate

Выход 60.2%

Растворители

triethylamine

Условия реакции

Обработка

1. 1
   Другоеsparged with argon for 5 minutes

Методика

Using General Procedure F; 4-ethynyl-2-isopropyl-1-(1-methyl-cyclopropoxymethyl)-benzene (Intermediate 166, 78.0 mg, 0.34 mmol) and methyl-(4-iodophenyl)-acetate (Reagent B, 94.0 mg, 0.34 mmol) in triethylamine (8 mL) was treated with copper(I)iodide (22.0 mg, 0.11 mmol) and sparged with argon for 5 minutes. Dichlorobis(triphenylphosphine)palladium(II) (79 mg, 0.11 mmol) was added and the reaction mixture was stirred at room temperature for 3.5 hours. Column chromatography (2-5% EtOAc—hexanes) afforded 77.0 mg (60%) of the title compound as a yellow oil.

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