Реакция #5254

Уравнение реакции

7-amino-cephalosporanic acid

boron trifluoride

allyl alcohol

→

3-allyloxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

Растворители

triethylamine

Условия реакции

Обработка

1. 1
   Другоеwere reacted
2. 2
   Другоеthe 9 g of raw product was purified successively twice with hot hydrochloric acid and ammonium hydroxide

Методика

Using the procedure of Step A of Example 8, 27.2 g of 7-amino-cephalosporanic acid, 170 ml of the etherate of boron trifluoride, 136 ml of allyl alcohol and 115 ml of triethylamine were reacted and the 9 g of raw product was purified successively twice with hot hydrochloric acid and ammonium hydroxide to obtain 4.72 g of 3-allyloxymethyl-7-amino-ceph-3-eme-4-carboxylic acid.

Источник