Реакция #52407

Уравнение реакции

triethyl amine

Intermediate 51

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

(trimethylsilyl)acetylene

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

→

title compound

1-Cyclopropyl-6-trimethylsilanylethynyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Растворители

tetrahydrofuran

Условия реакции

Методика

Following general procedure D and using 6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline (Intermediate 51, 0.8 g, 2.86 mmol), (trimethylsilyl)acetylene (5 mL, 35 mmol), triethyl amine (10 mL), anhydrous tetrahydrofuran, copper(I)iodide (0.080 g, 0.42 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.240 g, 0.34 mmol), the title compound was obtained as an oil (0.67 g, 79%).

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