Реакция #52236

Уравнение реакции

1-Boc-isonipecotic acid

BH3-THF

→

l-Boc-piperidine-4-methanol

Выход 85.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Температураto warm to room temperature for 12 h
2. 2
   ДругоеThe mixture was carefully quenched with water
3. 3
   workup.ADDITIONdiluted with ethyl acetate
4. 4
   ЭкстракцияThe water layer was extracted with ethyl acetate
5. 5
   Промывкаwashed with brine
6. 6
   Сушкаdried (Na2SO4)
7. 7
   Фильтрацияfiltered
8. 8
   Концентрированиеconcentrated

Методика

1-Boc-isonipecotic acid (10.0 g, 214 mmol) was dissolved in THF (400 mL) and cooled to 0° C. A solution of BH3-THF (180 mL, 1 N in THF, 180 mmol) was added slowly. The mixture stirred for 1 h at 0° C. and was allowed to warm to room temperature for 12 h. The mixture was carefully quenched with water and diluted with ethyl acetate. The water layer was extracted with ethyl acetate. The organic layers were combined, washed with brine, dried (Na2SO4), filtered and concentrated to provide l-Boc-piperidine-4-methanol (7.98 g, 85%) as a white solid.

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