Реакция #521664

Уравнение реакции

BOC-leucinal

sodium borohydride

→

BOC-leucinol

Выход 76.7%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe methanol was removed in vacuo
2. 2
   Экстракцияextracted with ether (3×)
3. 3
   ПромывкаThe combined ethereal extracts were washed with saturated NaCl (aq) (2×)
4. 4
   Сушкаdried over MgSO4
5. 5
   Фильтрацияfiltered

Методика

To a solution of BOC-leucinal (168 mg, 0.780 mmol) in methanol (2 ml) cooled to 0° C., was added sodium borohydride (30 mg, 0.780 mmol). After stirring 15 min, the reaction was complete by TLC. The methanol was removed in vacuo and the resulting residue slurried with water and extracted with ether (3×). The combined ethereal extracts were washed with saturated NaCl (aq) (2×), dried over MgSO4, and filtered. The filtrate was stripped to dryness in vacuo to give 130 mg of BOC-leucinol as a colorless oil with properties identical to those described above in Example 1, Step A.

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