Реакция #52154

Уравнение реакции

N-BOC-octahydroisoindole-1-carboxylic acid

→

octahydroisoindole-1-carboxylic acid

Выход 131.2%

Растворители

HCl

dioxane

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated in vacuo
2. 2
   Другоеtriturated with Et2O (2×70 mL)
3. 3
   Другоеdried in vacuo

Методика

N-BOC-octahydroisoindole-1-carboxylic acid (18.6 mmol) was dissolved in 4 M HCl in dioxane (46.5 mL) at rt. After stirring for 1 hr, the reaction was determined to be complete by TLC. The reaction mixture was concentrated in vacuo, triturated with Et2O (2×70 mL) and then dried in vacuo to afford octahydroisoindole-1-carboxylic acid (4.13 g) as a white solid.

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