Реакция #51961

Уравнение реакции

tert-butyl 2-{4-[(dimethylamino)methyl]phenyl}-2-hydroxyethyl(methyl)carbamate

→

title compound

Выход 106.8%

1-{4-[(Dimethylamino)methyl]phenyl}-2-(methylamino)ethanol

Выход 106.8%

Растворители

HCl dioxane

Условия реакции

Обработка

1. 1
   ДругоеThe solvent and HCl was evaporated
2. 2
   workup.ADDITIONAfter treated with high vacuum for 15 minutes
3. 3
   workup.DISSOLUTIONthe residue was dissolved in methanol (2 mL)
4. 4
   workup.ADDITIONtreated with resin (BioRad 50w×2, 0.20 g) for 3 hours
5. 5
   ФильтрацияThe resin was collected by filtration
6. 6
   Промывкаwashed with methanol
7. 7
   ПромывкаThe product on the resin was washed off with NH4OH/CH3OH (20 mL, 10% ammonium hydroxide aqueous solution (Aldrich, 29.4% NH3) in methanol)
8. 8
   КонцентрированиеThe solution was concentrated to dryness
9. 9
   workup.ADDITIONtreated with high vacuum

Методика

To a solution of HCl-dioxane (20 mL, 4.0 M HCl in dioxane) was added tert-butyl 2-{4-[(dimethylamino)methyl]phenyl}-2-hydroxyethyl(methyl)carbamate (124 mg, 0.40 mmol). The mixture was stirred at room temperature for 16 hours. The solvent and HCl was evaporated. After treated with high vacuum for 15 minutes, the residue was dissolved in methanol (2 mL) and treated with resin (BioRad 50w×2, 0.20 g) for 3 hours. The resin was collected by filtration and washed with methanol. The product on the resin was washed off with NH4OH/CH3OH (20 mL, 10% ammonium hydroxide aqueous solution (Aldrich, 29.4% NH3) in methanol). The solution was concentrated to dryness, and treated with high vacuum to give the title compound (89 mg) as an oil.

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