Реакция #51890

Уравнение реакции

3-trifluoromethyl 4-fluoro-benzonitrile

diethanolamine

→

3-trifluoromethyl-4-[bis(2-hydroxyethyl)amino]benzonitrile

Растворители

N,N-dimethylacetamide

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated
2. 2
   Другоеthe residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
3. 3
   Сушкаthe organic layer dried (MgSO4)
4. 4
   Другоеevaporated to dryness
5. 5
   ДругоеThe residue was chromatographed

Методика

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

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