Реакция #51850

Уравнение реакции

1,2-diphenyl-4-(4-methylphenyl)-3,5-pyrazolidinedione

H2O2

Sodium metabisulfite

→

1,2-Diphenyl-4-hydroxy-4-(4-methylphenyl)-3,5-pyrazolidinedione

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Другоеexcess acetic acid evaporated off
2. 2
   workup.DISSOLUTIONThe residue was dissolved in hot ethyl acetate (25 ml)
3. 3
   Фильтрацияbenzene (25 ml) and filtered
4. 4
   ТемператураAfter cooling to room temperature
5. 5
   Фильтрацияthe mixture was filtered
6. 6
   Другоеthe residue recrystallized from 50% aqueous ethanol (20 ml)
7. 7
   Другоеto give 0.58 g (53%)

Методика

A mixture of 1,2-diphenyl-4-(4-methylphenyl)-3,5-pyrazolidinedione (1.10 g; 3.2 =mol), 35% H2O2 (0.47 ml; 5.5 mmol), and acetic acid (40 ml) was stirred 16 days at room temperature. Sodium metabisulfite (1.0 g) was added and excess acetic acid evaporated off. The residue was dissolved in hot ethyl acetate (25 ml) and benzene (25 ml) and filtered. After cooling to room temperature, the mixture was filtered and the residue recrystallized from 50% aqueous ethanol (20 ml) to give 0.58 g (53%).

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