Реакция #51839

Уравнение реакции

water

hydantoin

potassium carbonate

benzyl bromoacetate

→

phenylmethyl 2-(2,5-dioxoimidazolidinyl)acetate

Выход 60.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture was extracted with ethyl acetate
2. 2
   ПромывкаThe organic phase was washed with 5% aqueous citric acid solution and brine
3. 3
   СушкаThe organic phase was dried over anhydrous magnesium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated under reduced pressure
6. 6
   ПромывкаThe crystalline residue was washed with diethyl ether
7. 7
   Другоеdried

Методика

To a solution of hydantoin (10.0 g, 0.10 mol) in DMF (100 ml) at 60° C. were added potassium carbonate (20.7 g, 0.15 mol) and benzyl bromoacetate (18.9 ml, 0.12 mol). After stirring the mixture at 60° C. overnight, the reaction mixture was poured into water (250 ml) and the mixture was extracted with ethyl acetate. The organic phase was washed with 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The crystalline residue was washed with diethyl ether, and dried to give phenylmethyl 2-(2,5-dioxoimidazolidinyl)acetate (14.9 g).

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