Реакция #51766

Уравнение реакции

MeOH

(2-tert-butyoxycarbonylamino-4-isopropyl-5-thiocyanato-phenyl)-carbamic acid tert-butyl ester

sodium hydrogen sulfide

sodium borohydride

→

title compound

(2-tert-Butyoxycarbonylamino-4-isopropyl-5-mercapto-phenyl)-carbamic acid tert-butyl ester

Растворители

H2O

AcOH

Условия реакции

Обработка

1. 1
   ДругоеThe crude product was used without any purification

Методика

The title compound was prepared according to General Method 14b using (2-tert-butyoxycarbonylamino-4-isopropyl-5-thiocyanato-phenyl)-carbamic acid tert-butyl ester (prepared in Example SS-1; 9 g, 22 mmol), sodium hydrogen sulfide (3.7 g, 66 mmol), sodium borohydride (5.02 g, 132 mmol), MeOH (20 mL), H2O (5 mL), and AcOH (2 mL). The crude product was used without any purification. MS(APCI): 381 (M−H).

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