Реакция #51755

Уравнение реакции

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

HCl

→

title compound

6-tert-Butyl-2,3-dihydro-1H-indole

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   Другоеwas cooled to 0° C.
2. 2
   ДругоеThe solvents were evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in EtOAc
4. 4
   Промывкаwashed with saturated NaHCO3 solution and brine
5. 5
   Другоеdried
6. 6
   Концентрирование(MgSO4.) Concentration

Методика

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (Prepared in Example HH; 12.0 g) in CH2Cl2 (100 mL) was cooled to 0° C. and treated with HCl gas for 10 minutes. The reaction mixture was warmed to room temperature and stirred for 1 hour. The solvents were evaporated; the residue was dissolved in EtOAc, washed with saturated NaHCO3 solution and brine, and dried (MgSO4.) Concentration gave the title compound which was used without any further purification. MS(APCI): 176 (M+H).

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