Реакция #51658

Уравнение реакции

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

→

7-methoxy-3-methylsulfanyl-1H-indole

Выход 87.5%

Растворители

DMSO

Условия реакции

Обработка

1. 1
   Другоеplaced under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
2. 2
   ДругоеThe flask was placed on a steam bath
3. 3
   Температураheated until the bubbling
4. 4
   Температураthe reaction mixture was cooled
5. 5
   Другоеpartitioned between ether and water
6. 6
   ДругоеThe organic layer was dried
7. 7
   Фильтрацияfiltered
8. 8
   Другоеevaporated to dryness

Методика

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

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