Реакция #51458

Уравнение реакции

5-chlorocarbonylphthalid

morpholine

triethylamine

→

5-(4-morpholylcarbonyl)phthalid

Растворители

THF

THF

Условия реакции

Обработка

1. 1
   ДругоеTHF is evaporated off in vacuo
2. 2
   ТемператураThe solution is cooled to 5° C.
3. 3
   Промывкаwashed with water (100 ml)

Методика

A solution of 5-chlorocarbonylphthalid (39 g, 0.2 mole) in THF (400 ml) is added to a solution of morpholine (22 g. 0.25 mole) and triethylamine (26 g, 0.25 mole) in THF (200 ml) at 0° C. The mixture is stirred for 1 hour and is allowed to warm to room temperature. The reaction mixture is then poured into ice water ( 500 ml). THF is evaporated off in vacuo and the pH of the solution is adjusted to pH=2. The solution is cooled to 5° C. and the precipitated crystals are filtred off and washed with water (100 ml).

Источник