Реакция #5144

Уравнение реакции

2-(2-(2-chloroethoxy)ethoxy)-ethanol

m-nitrophenol

N,N-dimethylformamide

potassium carbonate

→

2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol

Растворители

water

ethyl acetate

Условия реакции

Обработка

1. 1
   workup.STIRRINGAfter stirring the mixture for one hour at 80° C.
2. 2
   Экстракцияthe ethyl acetate layer was extracted
3. 3
   ПромывкаThe ethyl acetate layer was washed with 200 ml of water
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеto remove ethyl acetate

Методика

While stirring a mixture of 27.8 g of m-nitrophenol, 120 ml of N,N-dimethylformamide, and 25 g of potassium carbonate at 80° C., 37 g of 2-(2-(2-chloroethoxy)ethoxy)-ethanol was added dropwise to the mixture. After stirring the mixture for one hour at 80° C., 200 ml of ethyl acetate and 200 ml of water were added to the reaction mixture and the ethyl acetate layer was extracted. The ethyl acetate layer was washed with 200 ml of water and concentrated to remove ethyl acetate to provide 2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol (1-A).

Источник