Реакция #51346

ord-7d225e1005844bdd97d5e8ce53944117

Уравнение реакции

O=C(O)Cc1ccc(Cl)c(Cl)c1
3,4-dichlorophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccc(Cl)c(Cl)c1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccc(Cl)c(Cl)c1
N-[(3,4-dichlorophenyl)acetyl]-L-alanine iso-butyl ester

Реактанты

O=C(O)Cc1ccc(Cl)c(Cl)c1
3,4-dichlorophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Экстракцияwas by extraction with Et2O

Методика

Following General Procedure BB and using 3,4-dichlorophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 81°-83° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06849650B2uspto-grants-2005_02