Реакция #5110

Уравнение реакции

6-(4-Chlorophenyl)-4,6-diketohexanol

2-hydrazino-6-methoxybenzothiazole

→

title compound 6

Выход 80.9%

5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(6-methoxy-2-benzothiazolyl)pyrazole

Выход 80.9%

Растворители

pyridine

MeOH

Условия реакции

Обработка

1. 1
   Температураat reflux for 72 hr
2. 2
   Другоеfollowed by recrystallization from MeOH

Методика

6-(4-Chlorophenyl)-4,6-diketohexanol (14.43 g, 60 mM) was treated with 2-hydrazino-6-methoxybenzothiazole (11.72 g, 60 mM) in pyridine (10 ml) and MeOH (300 ml) at reflux for 72 hr. Work-up as described in Example 1 followed by recrystallization from MeOH afforded the title compound 6 as a white solid (19.4 g), mp=123°-125° C.; NMR(CDCl3) δ 6.3 (s, 1H, C4 -H); MS, m/e 399 (M+).

Источник