Реакция #508164

ord-cfe4004987614c3b88e089cc1b1b4bc9

Уравнение реакции

CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(N(CC)CC)cc1
1-(4-diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester
CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(N(CC)CC)cc1
1-(4-Diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester
OB(O)c1ccc2ccccc2c1
2-naphthyl-boronic acid
CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3ccc4ccccc4c3)ccc2n1-c1ccc(N(CC)CC)cc1
sub-title compound
CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3ccc4ccccc4c3)ccc2n1-c1ccc(N(CC)CC)cc1
1-(4-Diethylaminophenyl)-5-(2-naphthyloxy)-2-ethoxycarbonylmethylindole-3-carboxylic acid ethyl ester

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The sub-title compound was prepared in accordance with step (c) Example 1 from 1-(4-diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester (150 mg, 0.35 mmol, see step (b) Example 1) and 2-naphthyl-boronic acid (91 mg, 0.53 mmol). Yield 66 mg, (34%).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08097623B2uspto-grants-2012_01