Реакция #50757

Уравнение реакции

2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetic acid hydrate

phosphorus pentachloride

isopropyl ether

→

title compound

Выход 106.0%

2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetyl chloride . hydrochloride

Выход 106.0%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   Другоеto precipitate crystals
2. 2
   ФильтрацияThe resulting crystals were collected by filtration
3. 3
   Промывкаwashed with 20 ml of isopropyl ether
4. 4
   Другоеdried

Методика

In 50 ml of methylene chloride, 10.0 g (0.044 mol) of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetic acid hydrate were suspended, followed by the addition of 13.3 g (0.064 mol) of phosphorus pentachloride at -20° C. After stirring for 30 minutes, 100 ml of isopropyl ether were added dropwise to the reaction mixture to precipitate crystals. The resulting crystals were collected by filtration, washed with 20 ml of isopropyl ether and then dried, whereby 9.33 g of a title compound were obtained (yield: 77%, purity: 89.7%).

Источник