Реакция #5063

Уравнение реакции

3-bromoquinoline

butyllithium

1-methylpiperid-4-one

→

expected product

Выход 53.8%

3-(4-Hydroxy-1-methylpiperid-4-yl)quinoline

Выход 53.8%

Растворители

hexane

Условия реакции

Методика

95.01 g of 3-bromoquinoline were treated with 200 ml of a 2.5M solution of butyllithium in hexane and 51.62 g of 1-methylpiperid-4-one in accordance with the procedure described in Stage A of Example 1, in order to obtain the expected product.

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