Реакция #5061

Уравнение реакции

hydrogen chloride

compound

4-(naphth-1-yl)piperidine hydrobromide

potassium carbonate

bromoacetonitrile

→

hydrochloride

Выход 91.8%

(4-Naphth-1-ylpiperid-1-yl)acetonitrile hydrochloride

Выход 91.8%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   ФильтрацияAfter filtering
3. 3
   Другоеevaporation of the filtrate
4. 4
   Другоеthe residue obtained

Методика

5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.

Источник