Реакция #50494

Уравнение реакции

2-nitroiminothiazolidine

potassium carbonate

2-chloro-5-pyridylmethylchloride

→

3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 5 hours
2. 2
   ДругоеAfter the reaction
3. 3
   Другоеmost of the acetonitrile was removed by distillation and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ДругоеAs the solid product was separated
6. 6
   Фильтрацияit was collected by filtration
7. 7
   ДругоеThe crude material was recrystallized from ethanol

Методика

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

Источник