Реакция #50404

Уравнение реакции

ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate

→

3-(2-(4-Toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoic acid

Растворители

ethanol

—

15N sodium hydroxide

Условия реакции

Обработка

1. 1
   ПромывкаThen the cooled solution is washed 3 times with 50 ml of methylene chloride
2. 2
   ДругоеThe precipitate formed
3. 3
   Промывкаis washed
4. 4
   Другоеdried
5. 5
   Другоеrecrystallised from n-butanol

Методика

4.2 g of ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate are refluxed for 30 minutes in 40 ml of ethanol and 1.5 ml of 15N sodium hydroxide solution. Then the cooled solution is washed 3 times with 50 ml of methylene chloride and then acidified. The precipitate formed is washed, dried and then recrystallised from n-butanol.

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